A few of the papers today mention the latest progress on creating genetically modified mosquitoes to defeat malaria. See for instance this front page headline article in today's Guardian. Researchers at Johns Hopkins and Imperial College have been testing the new breed of mosquitoes, and have so far found success. The GM mosquitoes have their genes modified so they cannot carry the plasmodium parasite. The idea is that they would be released (in their millions) to quickly become the dominant species. Trials in West Africa are feasible within five years, should the scientists prove that a) the risk of creating a new superstrain of the parasite is minimised and b) the parasite does not switch to other carrier animals.
Of course, a focus on sewage and sanitation systems in Sub-Saharan Africa would also do much to destroy the parasite's effectiveness.